diff --git a/moto/backend_index.py b/moto/backend_index.py
index 81bc73472c9f..78a888e94b20 100644
--- a/moto/backend_index.py
+++ b/moto/backend_index.py
@@ -49,6 +49,7 @@
     ("ds", re.compile("https?://ds\\.(.+)\\.amazonaws\\.com")),
     ("dsql", re.compile("https?://dsql\\.(.+)\\.api\\.aws")),
     ("dynamodb", re.compile("https?://dynamodb\\.(.+)\\.amazonaws\\.com")),
+    ("dynamodb", re.compile("https?://(.+).ddb\\.(.+)\\.amazonaws\\.com")),
     (
         "dynamodbstreams",
         re.compile("https?://streams\\.dynamodb\\.(.+)\\.amazonaws.com"),
diff --git a/moto/dynamodb/urls.py b/moto/dynamodb/urls.py
index 59f70de77a5d..a8c632e4926b 100644
--- a/moto/dynamodb/urls.py
+++ b/moto/dynamodb/urls.py
@@ -1,5 +1,8 @@
 from .responses import DynamoHandler
 
-url_bases = [r"https?://dynamodb\.(.+)\.amazonaws\.com"]
+url_bases = [
+    r"https?://dynamodb\.(.+)\.amazonaws\.com",
+    r"https?://(.+).ddb\.(.+)\.amazonaws\.com",
+]
 
 url_paths = {"{0}/": DynamoHandler.dispatch}
diff --git a/tests/test_dynamodb/test_dynamodb_account_mode.py b/tests/test_dynamodb/test_dynamodb_account_mode.py
new file mode 100644
index 000000000000..9d9289f10aca
--- /dev/null
+++ b/tests/test_dynamodb/test_dynamodb_account_mode.py
@@ -0,0 +1,26 @@
+import boto3
+import pytest
+from botocore.config import Config
+
+from moto import mock_aws
+from moto.core import DEFAULT_ACCOUNT_ID as ACCOUNT_ID
+
+
+@mock_aws
+@pytest.mark.parametrize("endpoint_mode", ["disabled", "preferred", "required"])
+def test_dynamodb_with_account_id_routing(endpoint_mode):
+    endpoint_config = Config(account_id_endpoint_mode=endpoint_mode)
+    client = boto3.client(
+        "dynamodb",
+        aws_access_key_id="ACCESS_KEY",
+        aws_secret_access_key="SECRET_KEY",
+        aws_account_id=ACCOUNT_ID,
+        region_name="us-west-2",
+        config=endpoint_config,
+    )
+    client.create_table(
+        TableName="test",
+        KeySchema=[{"AttributeName": "id", "KeyType": "HASH"}],
+        AttributeDefinitions=[{"AttributeName": "id", "AttributeType": "S"}],
+        ProvisionedThroughput={"ReadCapacityUnits": 5, "WriteCapacityUnits": 5},
+    )