From c3261c37d13170211e860d7fd32f1ec353fd09ed Mon Sep 17 00:00:00 2001 From: Nina Di Cara Date: Fri, 28 Jun 2024 13:50:14 +0100 Subject: [PATCH 1/2] Add synthetic biology Hazards for v1.1 --- site/hazards/ecological-harm.md | 20 +++++ site/hazards/experimental-hazard.md | 18 +++++ site/hazards/incompatible-data.md | 18 +++++ site/hazards/uncertain-accuracy.md | 18 +++++ site/hazards/uncertain-completeness.md | 18 +++++ site/images/hazards/ecological-harm.png | Bin 0 -> 32607 bytes site/images/hazards/experimental-hazard.png | Bin 0 -> 37725 bytes site/images/hazards/incompatible-data.png | Bin 0 -> 49266 bytes site/images/hazards/uncertain-accuracy.png | Bin 0 -> 34973 bytes .../images/hazards/uncertain-completeness.png | Bin 0 -> 29303 bytes site/labels.md | 71 ++++++++++++++++-- 11 files changed, 158 insertions(+), 5 deletions(-) create mode 100644 site/hazards/ecological-harm.md create mode 100644 site/hazards/experimental-hazard.md create mode 100644 site/hazards/incompatible-data.md create mode 100644 site/hazards/uncertain-accuracy.md create mode 100644 site/hazards/uncertain-completeness.md create mode 100644 site/images/hazards/ecological-harm.png create mode 100644 site/images/hazards/experimental-hazard.png create mode 100644 site/images/hazards/incompatible-data.png create mode 100644 site/images/hazards/uncertain-accuracy.png create mode 100644 site/images/hazards/uncertain-completeness.png diff --git a/site/hazards/ecological-harm.md b/site/hazards/ecological-harm.md new file mode 100644 index 0000000..e7abde1 --- /dev/null +++ b/site/hazards/ecological-harm.md @@ -0,0 +1,20 @@ +# Synthetic Biology Data Hazard: Capable of Ecological Harm + +```{image} ../images/hazards/ecological-harm.png +:alt: A red diamond shaped outline (like a warning sign) with a dead fish in a stream next a bare tree. +:width: 250px +``` + +[Icon adapted from the [Health and Safety Executive](https://www.hse.gov.uk/chemical-classification/labelling-packaging/hazard-symbols-hazard-pictograms.htm) under the [Open Government License 3.0](https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/)] + +## Description + +This technology has the potential to cause broad ecological harm, even if used correctly. + +## Examples + +__Example 1:__ Gene drives used to cause extinction events and in situ engineering of microbiomes. + +## Safety Precautions + +Ensure sufficient physical containment to avoid unexpected release and barriers in place if deployed. \ No newline at end of file diff --git a/site/hazards/experimental-hazard.md b/site/hazards/experimental-hazard.md new file mode 100644 index 0000000..1370461 --- /dev/null +++ b/site/hazards/experimental-hazard.md @@ -0,0 +1,18 @@ +# Synthetic Biology Data Hazard: Potential Experimental Hazard + +```{image} ../images/hazards/experimental-hazard.png +:alt: A red diamond shaped outline (like a warning sign) with a flask containing an exclamation mark. +:width: 250px +``` + +## Description + +Translating technology into experimental practice can require safety precautions + +## Examples + +__Example 1:__ Toxin production, virus-like particles, work with potentially pathogenic microbes. + +## Safety Precautions + +Assess possible safety issues and put in place necessary safety measures. \ No newline at end of file diff --git a/site/hazards/incompatible-data.md b/site/hazards/incompatible-data.md new file mode 100644 index 0000000..b7ccc35 --- /dev/null +++ b/site/hazards/incompatible-data.md @@ -0,0 +1,18 @@ +# Synthetic Biology Data Hazard: Integration of Incompatible Data + +```{image} ../images/hazards//incompatible-data.png +:alt: A red diamond shaped outline (like a warning sign) containing two arrows coming in from different directions that point to an exclamation mark. +:width: 250px +``` + +## Description + +Data of different types and/or sources are being used together that may not be compatible with each other. + +## Examples + +__Example 1__: Models that need to integrate information about many different processes in a cell. + +## Safety Precautions + +Convert data to compatible format where possible of collect complementary data that is compatible. \ No newline at end of file diff --git a/site/hazards/uncertain-accuracy.md b/site/hazards/uncertain-accuracy.md new file mode 100644 index 0000000..1924230 --- /dev/null +++ b/site/hazards/uncertain-accuracy.md @@ -0,0 +1,18 @@ +# Synthetic Biology Data Hazard: Uncertain Accuracy of Source Data + +```{image} ../images/hazards/uncertain-accuracy.png +:alt: A red diamond shaped outline (like a warning sign) with a target symbol in the middle. +:width: 250px +``` + +## Description + +The accuracy of the underlying data is not known and so its use may lead to erroneous results or introduce bias. + +## Examples + +__Example 1__: Metabolic modelling where inaccurately labelled conversions (e.g. due to computational prediction) might lead to unexpected products being produced by engineered pathways. + + +## Safety Precautions +Attempt to classify uncertainty if possible to better inform decisions and understand the range of possible outcomes. \ No newline at end of file diff --git a/site/hazards/uncertain-completeness.md b/site/hazards/uncertain-completeness.md new file mode 100644 index 0000000..9af9996 --- /dev/null +++ b/site/hazards/uncertain-completeness.md @@ -0,0 +1,18 @@ +# Synthetic Biology Data Hazard: Uncertain Completeness of Source Data + +```{image} ../images/hazards/uncertain-completeness.png +:alt: A red diamond shaped outline (like a warning sign) containing three puzzle pieces that are not connected together. +:width: 250px +``` + +## Description + +Underlying data is of an uncertain completeness and have missing values that causes biased results. + +## Examples + +__Example 1__: Whole-cell models which attempt to use all the data available, but which may be limited. 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+:::::{grid} 1 2 3 3 +:margin: 4 4 0 0 +:gutter: 2 + +::::{grid-item-card} Uncertain Accuracy of Source Data +:img-top: images/hazards/uncertain-accuracy.png +:img-alt: A red diamond shaped outline (like a warning sign) with a target symbol in the middle. +:link: /hazards/uncertain-accuracy +:link-type: doc + +The accuracy of the underlying data is not known and so its use may lead to erroneous results or introduce bias. +:::: + +::::{grid-item-card} Uncertain Completeness of Source Data +:img-top: /images/hazards/uncertain-completeness.png +:img-alt: A red diamond shaped outline (like a warning sign) containing three puzzle pieces that are not connected together. +:link: hazards/uncertain-completeness +:link-type: doc + +Underlying data is of an uncertain completeness and have missing values that causes biased results. +:::: + +::::{grid-item-card} Integration of Incompatible Data +:img-top: /images/hazards/incompatible-data.png +:img-alt: A red diamond shaped outline (like a warning sign) containing two arrows coming in from different directions that point to an exclamation mark. +:link: hazards/incompatible-data +:link-type: doc + +Data of different types and/or sources are being used together that may not be compatible with each other. +:::: + +::::{grid-item-card} Capable of Ecological Harm +:img-top: /images/hazards/ecological-harm.png +:img-alt: A red diamond shaped outline (like a warning sign) with a dead fish in a stream next a bare tree. +:link: hazards/ecological-harm +:link-type: doc + +This technology has the potential to cause broad ecological harm, even if used correctly. +[Image adapted from the [Health and Safety Executive](https://www.hse.gov.uk/chemical-classification/labelling-packaging/hazard-symbols-hazard-pictograms.htm) under the [Open Government License 3.0](https://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/)] +:::: + +::::{grid-item-card} Potential Experimental Hazard +:img-top: /images/hazards/experimental-hazard.png +:img-alt: A red diamond shaped outline (like a warning sign) with a flask containing an exclamation mark. +:link: hazards/experimental-hazard +:link-type: doc + +Translating technology into experimental practice can require safety precautions. +:::: + +::::: ## Future development @@ -142,7 +199,7 @@ Suggestions for future versions of the Data Hazard labels are curated as GitHub The change log records when changes that have been made to the project and gives a brief description of what the changes were. The change log started in March 2022. -The most recent changes should be at the top of the list. +The most recent changes are at the top of the list. +__21.06.2024: v1.1 - Add Synthetic Biology Hazard labels__ +Changes made by [@ninadicara](https://github.com/ninadicara) to reflect new additions formally proposed by +authors of [the paper in Synthetic Biology](https://doi.org/10.1093/synbio/ysae010). + __29.05.2024: Put labels in alphabetical order__ [@ninadicara](https://github.com/ninadicara) From 1590e26e3521b87828f549cb8e306d22bfc2ce00 Mon Sep 17 00:00:00 2001 From: Nina Di Cara Date: Fri, 28 Jun 2024 15:10:31 +0100 Subject: [PATCH 2/2] Add citation --- site/labels.md | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/site/labels.md b/site/labels.md index 4b84edf..ace1797 100644 --- a/site/labels.md +++ b/site/labels.md @@ -134,7 +134,7 @@ This technology may risk the privacy of individuals whose data is processed by i ### Extensions for Synthetic Biology -[Read the accompanying paper here.](https://doi.org/10.1093/synbio/ysae010) +[Zelenka, Natalie R., et al. "Data hazards in synthetic biology." _Synthetic Biology_ (2024): ysae010.](https://doi.org/10.1093/synbio/ysae010)