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Understanding the mechanisms underlying the lack of response to Janus kinase inhibition in ulcerative colitis

Elisa Melón-Ardanaz, Marisol Veny, Ana M. Corraliza, Alba Garrido-Trigo, Victoria Gudiño, Ángela Sanzo-Machuca, Marc Buendia, Miriam Esteller, Maite Rodrigo, M. Carme Masamunt, Ángel Giner, Ingrid Ordás, Agnès Fernández-Clotet, Berta Caballol, Ángel Corbí, Bram Verstock, Severine Vermeire, Julian Panés, Elena Ricart, Azucena Salas

Background and Aims: Tofacitinib, a Janus kinase inhibitor, is approved for the treatment of moderate-to-severe ulcerative colitis. Nonetheless, 40-60% of patients will not respond adequately. The mechanisms underlying responses to tofacitinib remain unknown.

Methods: We applied single-cell and/or bulk RNA analysis to biopsies (n=23 and 63, respectively) from ulcerative colitis patients (n= 31) before and after tofacitinib treatment. Response was assessed using endoscopic and clinical criteria. In vitro-derived macrophages and primary intestinal fibroblasts were used to validate our findings.

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This repository is composed of two main directories.

  • Figures: In this directory you can find the code to develop each figure of the study.
  • Analysis: In this directory you can find all the code to perform the same analysis of the study.

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