URL patterns and their differences between Explorer 1 and Explorer 2

Compound Info

• Exp1: http://explorer.openphacts.org/#!p=CmpdByNameForm&u=http://www.conceptwiki.org/concept/dd758846-1dac-4f0d-a329-06af9a7fa413
• Exp2: http://explorer2.openphacts.org/compounds?uri=http://www.conceptwiki.org/concept/dd758846-1dac-4f0d-a329-06af9a7fa413

Explorer 1	Explorer 2
#!p=CmpdByNameForm&u=	compounds?uri=

Compound Pharmacology

• Exp1: http://explorer.openphacts.org/#!p=PharmByCmpdNameForm&u=http://www.conceptwiki.org/concept/dd758846-1dac-4f0d-a329-06af9a7fa413
• Exp2: http://explorer2.openphacts.org/compounds/pharmacology?uri=http://www.conceptwiki.org/concept/dd758846-1dac-4f0d-a329-06af9a7fa413

Explorer 1	Explorer 2
#!p=PharmByCmpdNameForm&u=	compounds/pharmacology?uri=

Compound Draw

• Exp1: No URL, is a function of structure search form and the functionality is often broken due to third part dependencies
• Exp2: http://explorer2.openphacts.org/compounds/draw?smiles=CC1%3DC(C(%3DCC%3DC1)C(%3DO)O)OC(%3DO)C

URL pattern is compounds/draw?smiles= where the SMILES has been URL encoded.

Compound Structure Search

• Explorer 1 exact http://explorer.openphacts.org/#!p=SimSearchForm&sm=CC(=O)OC1=CC=CC=C1C(=O)O&st=exact

• Explorer 1 substructure http://explorer.openphacts.org/#!p=SimSearchForm&sm=CC(=O)OC1=CC=CC=C1C(=O)O&st=sub

• Explorer 1 similarity http://explorer.openphacts.org/#!p=SimSearchForm&sm=CC(=O)OC1=CC=CC=C1C(=O)O&st=sim

• Explorer 2 exact http://explorer2.openphacts.org/compounds/structure?smiles=CC(%3DO)OC1%3DCC%3DCC%3DC1C(%3DO)O&type=exact

• Explorer 2 substructure http://explorer2.openphacts.org/compounds/structure?match=0&records=100&smiles=CC(%3DO)OC1%3DCC%3DCC%3DC1C(%3DO)O&threshold=0.9&thresholdtype=0&type=substructure

• Explorer 2 similarity http://explorer2.openphacts.org/compounds/structure?match=0&records=100&smiles=CC(%3DO)OC1%3DCC%3DCC%3DC1C(%3DO)O&threshold=0.9&thresholdtype=0&type=similarity

The start of the URL pattern in Explorer 1 is #!p=SimSearchForm&sm= and in Explorer 2 is compounds/structure?smiles=

The URL then includes parameters defining the type of structure search:

Explorer 1	Explorer 2
&st=exact	&type=exact
&st=sub	&type=substructure
&st=sim	&type=similarity

There are also additional parameters for substructure and similarity search for threshold, match, records and thresholdtype. See the API docs for further details. Substructure only uses records and ignores the rest.

Target Info

• Explorer 1 http://explorer.openphacts.org/#!p=TargetByNameForm&u=http://www.conceptwiki.org/concept/b932a1ed-b6c3-4291-a98a-e195668eda49
• Explorer 2 http://explorer2.openphacts.org/targets?uri=http://www.conceptwiki.org/concept/b932a1ed-b6c3-4291-a98a-e195668eda49

Explorer 1	Explorer 2
#!p=TargetByNameForm&u=	targets?uri=

Target Pharmacology

• Explorer 1 http://explorer.openphacts.org/#!p=PharmByTargetNameForm&u=http://www.conceptwiki.org/concept/b932a1ed-b6c3-4291-a98a-e195668eda49
• Explorer 2 http://explorer2.openpahcts.org/targets/pharmacology?uri=http://www.conceptwiki.org/concept/b932a1ed-b6c3-4291-a98a-e195668eda49

Explorer 1	Explorer 2
#!p=PharmByTargetNameForm&u=	targets/pharmacology?uri=

Enzymes/Trees

Explorer 1 can only show the enzyme hierarchy.

• Explorer 1 http://explorer.openphacts.org/#!p=PharmEnzymeForm&ec=1.1.1.1
• Explorer 2 http://explorer2.openphacts.org/trees/pharmacology?uri=http%3A%2F%2Fpurl.uniprot.org%2Fenzyme%2F1.1.1.1

Explorer 1	Explorer 2
#!p=PharmEnzymeForm&ec=	trees/pharmacology?uri=

Explorer 2 can also show the other hierarchies available in API version 1.3+.

• Enzyme http://explorer2.openphacts.org/trees?ontology=enzyme
• ChEMBL http://explorer2.openphacts.org/trees?ontology=chembl
• ChEBI http://explorer2.openphacts.org/trees?ontology=chebi
• GO http://explorer2.openphacts.org/trees?ontology=go